Canine Uncommon Superficial Pyoderma Treated with Amoxicillin and Clavulanic Acid Association (Synulox N.D.): About Four Cases
Objectives
Canine pyoderma present very different clinical aspects which can correspond to pathogen agents, alone or associated, not very frequent or which pathogenicity is increased by previous inappropriate therapies. In this context, clavulanate-amoxicillin association (SYNULOX®) was tested for its efficacy.
Materials & Methods
Four dogs presented for a superficial pyoderma were examined.
|
Case 1 |
Female West Highland White Terrier |
Generalized superficial pyoderma, pain |
Proteus mirabilis |
|
Case 2 |
Male English setter |
Pyoderma localized to left hind limb, pain |
Escherichia coli |
|
Case 3 |
Male Airedale terrier |
Superficial extensive dorsal pyoderma, pain |
Staphylococcus intermedius Pseudomonas aeruginosa |
|
Case 4 |
Female Brittany fawn griffon |
Superficial extensive pyoderma, pruritus |
Staphylococcus intermedius |
Skin samples (for cytology, culture, antibiogram) were performed at D0, D21, D45. A biopsy was performed at D0. The treatment consisted of an antibiotherapy with amoxicillin and clavulanic acid (12,5 mg/kg twice daily during 45 days)
Results
Cases 1, 2 and 4 presented a great clinical improvement on day10 and clinical and bacteriological recovery on day 45. Case 3 showed improvement on Day 21 and recovered on Day 60.
Conclusion
Amoxicillin and clavulanic acid can be used for treatment of chronic and unusual superficial pyoderma, provided that the duration of treatment is at least 45 days. In case 3, the improvement can be explain by the sterilization of the strain of Staphylococcus intermedius and the suspension of corticotherapy which, by modifying the microbial flora of the pyoderma, permitted in an indirect way, an action on Pseudomonas aeruginosa.