Salvia lalesarica is a plant from the family Lamiaceae which grows all over the world. The plant has been used for its pro-appetite, energetic, diuretic, anti-convulsant, and analgesic effects. It has also believed that the plant is effective in gastric neuropathies. In some studies antifungal and antimicrobial effects of the plant are documented. In this study the water-soluble extract of the plant is used to control the experimental ischemia-reperfusion injuries (IRI) in kidney of rats. 42 male Sprague-Dawley rats were used in this study. The animals were randomly assigned into two equal groups. Under general anesthesia (90 mg/kg ketamine, 10 mg/kg xylazine, IP) and aseptic surgical conditions, right kidney of the animals was approached from right sublumbar region. A Rumel tourniquet was used to induce ischemia for 40 minutes in the kidney, followed by an hour, 24 hours and 7 days reperfusion (seven rats in each group). The animals were sacrificed thereafter. In treatment group the plant extract was administered orally (0.08-0.1 cc of undiluted extract) on 48, 24 and 0.5 hours before surgery. In control group the same amount of normal saline was administered. Following sacrificing the animals the right kidney was removed and fixed in 10% buffered formalin. The sections were stained by hematoxylin and eosine and studied under light microscope. Severe ATN, hyaline cast formation (thyroidization), hemorrhage, very thickened capsule due to infiltration of inflammatory cells, some glomerular changes and finally infarction could be seen in control group. In treatment group the injuries were only mild ATN and hemorrhage. It can be concluded that Salva lalesarica extract can protect the kidney against the IRI.