In March, 1986, a harbor seal pup was illegally removed from a beach and transported by private citizens. During transport the pup was inadvertently overheated. Upon admission to CMMC the 9.8 kg, full term male was photophobic with an increased respiratory rate and exhibited a swimming motion when placed in a cage. Over the next 24 hours coarse tremors, paddling and head thrashing were replaced with stupor, lack of menace refl-ex, and limited auditory and tactile response. Cerebral edema secondary to hyperthermia was diagnosed. Emergency treatment included dexamethasone (15 mg LV) and fluid replacement (25ml/lb/24 hours) via R gavage. Antibiotic therapy was initiated with Keflex (12mg/kg p.o. tid). A therapy of exercises similar to patterning in humans was instituted to facilitate voluntary neuromuscular activity. Progress was evident, allowing the pup independence. However, a continued lack of strong motor skills precluded the release of this animal.