Three months after capture, four of fourteen wild caught female Bonnethead sharks, Sphryna tiburo, displayed papules on the dorsal and ventral surfaces of the skin, on the head and along the lateral line. During physical examination, minimal pressure on the papules caused rupturing resulting in the excretions of a white purulent exudate containing traces of blood. Cultures were taken prior to administering Gentomycin I.M. Additional treatment consisted of Amoxicillin and Chloramphenicol given per os in the food once daily for fourteen consecutive days. Fusarium was the only organism consistently isolated from all four sharks. Other organisms cultured included Pseudomonas, Staphylococcus, and Vibrio although none of these were demonstrable by histopathology to be associated with the lesions. Mycotic hyphea was identified in the skin and underlying soft tissue supporting the diagnosis of Fusarium as the primary pathogen. Fusarium, a moniliaceaus hyphomycete, is common in soil and as a plant pathogen. It is emerging as an animal pathogen of hyalohyphomycosis, most commonly associated with burn victims or surgical patients. Fusarium has been identified as a pathogen of crocodiles, sea turtles, red fish, Atlantic salmon, crayfish, and shrimp.