HISTORY

A 7-year-old, intact male German Shepherd dog was visited for an acute onset of edema in ventral areas of the body. Previous medical history was unremarkable. Subcutaneous edema in scrotum, preputial area and distal limbs, and enlarged lymph nodes were found on physical exam. CBC was normal. Serum biochemical abnormalities were hypercholesterolemia and hypoalbuminemia. Urinalysis only showed proteinuria. FNA of peripheral lymph nodes was compatible with lymphoma. Additional tests were performed to stage lymphoma, confirm protein-losing nephropathy (PLN) and rule out other causes of PLN. Abdominal and thoracic radiographs and abdominal ultrasonography were normal. Serum leishmaniosis & ehrlichiosis titers were negative. Bone marrow cytology yielded normal results. Urine culture was negative, and urine protein/creatinine ratio was 15. Further diagnostic tests were blood pressure determinations and serum antithrombin III, which were also normal. Diagnosis of PLN and nephrotic syndrome associated with [sic].

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