A 12+ year old male broomtail grouper (Mycteroperca xenarcha) became inappetent in June 1997. It died in August after 2 months of complete inappetence. Gross necropsy revealed elevated nodules ranging in size from 2 millimeters (mm) to 3 centimeters (cm) in diameter in the oral cavity and stomach. Histopathology revealed that the oral lesions were composed of fronds of poorly differentiated squamous epithelium in a vascular stroma heavily infiltrated with leukocytes. Mitotic activity in the epithelium was minimal. These masses were identified as a squamous cell carcinoma of low grade malignancy. The masses in the stomach were composed of various sizes and shapes of acinar structures which protruded from the mucosa into the lumen. The epithelium forming the glandular tissue varied from fairly well differentiated with abundant eosinophilic granular cytoplasm to poorly differentiated with basophilic cytoplasm and a large vesicular nucleus. Mitotic figures were minimal. The masses were identified as a gastric adenocarcinoma. Currently, no explanation is available as to what factors contributed to the neoplastic changes.