Abstract: The high risk of neurology injury surgery is the procedure direct in spinal cord, that recurrent increase the deficit motor postoperatory. The object of this study is to determine the oneself effect of Metil-prednisolone (MP), Melatonine (Mel), Cyclosporine A (CsA) and Erythropoietin recombinant human (EPO) who to demonstrate neuroprotective effects in other studies. Improve the functionally motor and morphometric index after of spinal cord injury some a model of high risk neurology injury surgery. Own hypothesis is that the administration of the neuroprotection drug before of the to provoke the tissular damage (primary damage) isn't sufficient to avoid or minimize the damage provoke for biochemical and molecular unchain in the spinal cord (second damage). Used Sprage-Dowley Rats, to forming groups (n=7) for any drug. Any rat was to put under a one impact of the spinal cord (T9) whit a moderate intensity (12.5 cm) with help of the New York impactor device. The administration of drugs was preoperarory, transoperatory and postoperatory manner. The rats were evaluate functionally with the BBB and BBB additional scale, and morphometrically by a index of preservation, wanted a significance difference (P<0.05) between groups. Opposite of owns hypothesis none drug demonstrate a beneficent significant difference (P>0.05), instead the group of CsA to show additional damage (P<0.05) in comparison with the control group. Apparently the electrophysiological techics and the high experience of the neurosurgical physician is the only efficient neuroprotection in this moment to diminish or avoid the secondary damage after a high risk spinal cord surgery.

References

1.  Morota N, Deletis V, Constantini S, Fofler M, Cohen H, Epsein FJ. The role of motor evoked potentials during surgery for intramedullary spinal cord tumors. Neurosurgery 1997;41:1327-1336.

2.  Duffau H, Capelle L, Sichez J. Direct spinal cord electrical stimulations during surgery of intranedullary tumoral and vascular lesions. Stereotact Funct Neurosurg 198;71:180-189.

3.  Domount RJ, Okonkwo DO, Verma S, Hurlbert RJ, Boulos PT, Ellegala Db, Dumont AS,. Acute spinal cord injury, part I: pathophysiologic mechanism. Clin Neuropharmacol 2001;24 :254-264