Objectives

This study evaluated the effects of sevoflurane and propofol anesthesia on renal function of dogs with naturally acquired chronic renal failure.

Materials & Methods

The anesthetic procedures included: three hours using sevoflurane (1.5CAM) in O₂ flow of 30mL/kg/min, in a semiclosed-circuit, after induction with propofol at 10mg/kg, in bolus (P-S group), or after induction with sevoflurane (S-S group), and for the P group it was used only propofol in the same dose employed for induction. Evaluations were performed in six sessions and included creatinine clearance, serum creatinine and ureia, protein and glucose urinary excretion. The renal function evaluations were performed 30 minutes before anesthesia, two times during anesthesia, and one, two and five days after.

Results

All anesthetic procedures were well succeeded and animals recovered uneventfully. No renal toxicity were observed in any of the anesthetic protocols. However, during the transanesthetic period it was observed decrease in the glomerular filtration rate and mild impairment of the tubular function, only in the group receiving sevoflurane after induction with propofol.

Conclusion

Although no renal toxicity were noticed, anesthesia with sevoflurane after induction with propofol must be considered with caution for dogs with renal failure.

This work was supported by FAPESP-Brazil.