OBJECTIVES

The purpose of this study was to evaluate the possible cardiovascular alterations that may occur due to the use of buprenorphine in dogs anesthetized with desflurane.

MATERIALS

Eight adult healthy male and female mongrel dogs were used. The anesthetic induction was made using propofol (IV), and immediately after, the dogs were intubated and the tube was connected to a volatile anesthetic circuit, and desflurane was administrated at 1.5 MAC. During the experimental period, the dogs were maintained under controlled ventilation. After 15 minutes of anesthesia, the dogs received buprenorphine (0.02 mg/kg/IV). Heart rate (HR); systolic, diastolic and mean arterial blood pressure (SAP, DAP, and MAP, respectively); cardiac output (CO), central venous pressure (CVP) and pulmonary arterial pressure (PAP) were evaluated. The measurements were realized 20 minutes after induction (M1), 15 minutes after buprenorphine administration (M2); and at each 15 minutes after M2 (M3, M4 and M5). The numerical data were submitted to Tukey test (p<0.05).

RESULTS

After buprenorphine administration (M2), there was a reduction in cardiovascular values: HR, PAP, SAP, DAP and MAP. During all the study, these values remained lower than the initial values, but were within normal values to the species. The CO and CVP were also decreased, but not statistically significant.

CONCLUSION

The results allow us to conclude that buprenorphine reduces the cardiovascular values in dogs during desflurane anesthesia.