Introduction

Over the last decade nanoparticles in medicine have gone from theoretical to clinical trials. Their ability to potentially target disease and to manipulate the body at a molecular level has caused much of this excitement. Nanospectra developed nanoparticles, silicone core and a gold shells, have been shown to be non-toxic and will react with near infrared light causing thermal ablation of solid tumors. In this retrospective study we evaluate efficacy and assess safety of nanoparticles and laser induced thermal ablation of a variety of tumors in dogs and squamous cell carcinoma in cats.

Methods

65 cases treated from 2014–2020 and from three different facilities were included in the study. Data collected included signalment, toxicities, power of light used, tumor type, and responses. Animals All animals received infusion of nanoparticles followed by light therapy 24 hours later. Light therapy (810 nm) was applied to tumors using an external light source (sapphire laser). Animals were evaluated once a week for four weeks and then monthly.

Results

Laser light treated animals developed minimal toxicities, including complete death of tumor (necrosis) or mild self-resolving thermal burns. Responses varied based on tumor type, with mast cell tumors and soft tissue sarcoma having the best response. Some of the animals received a second laser application, which provided these animals longer control of their tumors.

Conclusion

Nanoparticle laser tumor ablation therapy can be applied to solid tumors with minimal side effects while providing anticancer effects.

Funding Information

None.