Cryoablation is now mainstream in the treatment of tumors and tumor-associated pain. The procedure is ideally performed using computed tomography and ultrasound guidance. Treatments can include tumors of bone, liver, kidney, lung, and soft tissues, and can be used to freeze nerves for pain relief. In this presentation we will discuss the utility and technical details for how to perform a cryoablation, with specific focus on safety and avoidance of complications.