Computer-aided design and manufacturing, and 3-dimensional (3D) printing have increased workflow efficiency and accuracy in human medicine, and find applications in neurologic, orthopedic, maxillofacial and oncologic surgery via the production of pre-surgical visualization models, cutting and drilling guides, and custom-made implants. The use of this technology is nascent in veterinary medicine, and offers the ability to produce individual custom-made biomedical devices and implants to reconstruct complex anatomic defects and restore function in oncologic surgery. This presentation will review different prototypes, preclinical and clinical cases using 3D printing and computer aided design and manufacturing as a novel planning and reconstructive approach to canine maxillofacial oncologic surgery. Some examples discussed will include among other things the use of a cutting and drilling guide to improve margin accuracy, surgical time, workflow and protection of the surrounding soft tissues in caudal maxillectomy, and a case of dorsal maxillary multilobular osteochondrosarcoma treated with 3D printed custom-made devices.