Stereotactic radiotherapy represents an opportunity to advance beyond palliation; it offers an opportunity for effective definitive-intent limb-sparing treatment for extremity osteosarcoma in dogs. However, many questions persist regarding optimal deployment of this powerful therapy: What is the ideal fractionation? How should it be sequenced with chemotherapy? What is the role of bisphosphonates? What defines proper case selection? During this talk, we’ll explore those questions. We’ll also touch on novel approaches that are currently be evaluated in trials, including minimally-invasive limb stabilization strategies, and use of radiation as an anti-metastatic agent for canine osteosarcoma.