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ABSTRACT OF THE WEEK

Today's Veterinary Practice
Volume 13 | Issue 4 (Jul-Aug 2023)

Immunosuppressant Therapy in Small Animal Medicine: What, When, and Why

Today's Vet Pract. Jul-Aug 2023;13(4):83-93. 49 Refs
Stuart A Walton1, Alexis Hoelmer
1 University of Florida College of Veterinary Medicine, Gainesville, Florida 32608, USA.

Author Abstract

Glucocorticoids are considered the mainstay of immunosuppressive therapy; however, clinicians should be aware of second-line or alternative agents.

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Archives Highlights:
Case series of maggot debridement therapy demonstrates safety and efficacy for treating problematic wounds in cats and dogs in Mexico.
Treatment was administered by applying 8-10 larvae per square cm surface area directly on the wound bed and covering the wound with a sterile polyester mesh, sutured to the skin. These were left on the wound for cycles of approximately 48 hours (24-72 hours); the cycles were repeated if more than 20% necrotic tissue remained after treatment. Review of these cases revealed that 80% of treated wounds achieved 100% debridement within 48-96 hours of treatment.
Association between highly pathogenic avian influenza outbreaks and weather conditions in Japan.
We found that higher average air temperatures two to three weeks prior, lower average wind speeds four weeks prior, and longer sunlight hours two and four weeks prior to outbreaks were significantly associated with increased risk of HPAI outbreaks in Japan. These results suggest that weather may influence environmental survival and transmission of the virus, as well as patterns of wild bird movement that could seed new outbreaks.
The 4 prokinetic drugs metoclopramide, cisapride, pyridostigmine, and capromorelin do not increase fecal output or food intake in healthy New Zealand rabbits (Oryctolagus cuniculus).
Every day, rabbits produced a median of 75 g (range, 9 to 145 g) of feces, 226 fecal pellets (range, 12 to 412 pellets), and 151 mL (range, 5 to 420 mL) of urine. Metoclopramide, cisapride, pyridostigmine, and capromorelin had no effect on fecal production (both weight and number of pellets), food intake, urine production, or water intake compared to placebo at 24, 48, or 72 hours after administration.
A public health campaign to increase awareness of the risk of dog bites in South Australia.
Over one third (36-37%) of dog owners and 25-29% of non-dog owners had been previously bitten by a dog, although most did not require medical attention. Approximately 70% of dog owners believed it was safe for strangers to approach their dog, 34-37% allowed children or other people to pat their dog without permission, and less than half separated their dog from visitors or delivery people. In contrast, few of the non-dog owners allowed their children to pat a dog without the owner's permission and only 2% allowed them to play with dogs without supervision.
Canine distemper outbreak and laryngeal paralysis in captive tigers (Panthera tigris).
All suspected and confirmed cases of CDV infections were significantly associated with laryngeal inflammation, which developed into paralysis in almost 50% of cases. Altogether, 50% of all tiger cases with chronic infection developed stridor at 314 days after virus infection. Therefore, laryngeal paralysis may result from CDV infection and degeneration, potentially affecting the peripheral and central nervous systems. This condition could pose a life-threatening risk to tigers.

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